Brca Refined Analysis of Sequence Tests: Risk And Penetrance
BRA-STRAP is a nation-wide study of over 15,000 Australian women at high-risk of breast cancer who have tested negative for mutations in BRCA1 and BRCA2, and 15,000 unaffected controls. Participants to BRA-STRAP include women attending Familial Cancer Clinics and women participating in Australian Research Studies.
We are performing targeted sequencing of BRCA1, BRCA2, PALB2, TP53, ATM, MLH1, MSH2, MSH6, PMS2, BARD1, BRIP1, CDH1, CHEK2, MRE11A, RAD50, NBN/NBS1, MUTYH, NF1, PTEN, RAD51C, STK11, FANCM, RECQL, RAD51D.
The BRA-STRAP study will enable Australian population-based specific estimates of mutation prevalence and penetrance, be combined with similar data from other international efforts including BRIDGES (European Commission) and CARRIERS (NIH) that will provide additional capacity for these analyses and facilitate the translation of this new testing model and new genetic information into clinical genetics services.
BRA-STRAP is funded by the National Breast Cancer Foundation (Australia) and the National Health Medical Research Council (Australia).